Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases
Human DNA2 (hDNA2) contains both a helicase and a nuclease domain within the same polypeptide. The nuclease of hDNA2 is involved in a variety of DNA metabolic processes. Little is known about the role of the hDNA2 helicase. Using bulk and single-molecule approaches, we show that hDNA2 is a processiv...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2016-09-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/18574 |