Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases

Human DNA2 (hDNA2) contains both a helicase and a nuclease domain within the same polypeptide. The nuclease of hDNA2 is involved in a variety of DNA metabolic processes. Little is known about the role of the hDNA2 helicase. Using bulk and single-molecule approaches, we show that hDNA2 is a processiv...

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Bibliographic Details
Main Authors: Cosimo Pinto, Kristina Kasaciunaite, Ralf Seidel, Petr Cejka
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-09-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/18574