Bone marrow-derived cPLA2α contributes to renal fibrosis progression

Bone marrow-derived cPLA2α contributes to renal fibrosis progression

The group IVA calcium-dependent cytosolic phospholipase A2 (cPLA2α) enzyme directs a complex “eicosanoid storm” that accompanies the tissue response to injury. cPLA2α and its downstream eicosanoid mediators are also implicated in the pathogenesis of fibrosis in many organs, including the kidney. We...

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Bibliographic Details
Main Authors: John R. Montford, Allison M.B. Lehman, Colin D. Bauer, Jelena Klawitter, Jost Klawitter, Joanna M. Poczobutt, Micah Scobey, Mary Weiser-Evans, Raphael A. Nemenoff, Seth B. Furgeson
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Journal of Lipid Research
Subjects:
eicosanoids
extracellular matrix
kidney
inflammation
lipidomics
phospholipases/A2
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520342401

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http://www.sciencedirect.com/science/article/pii/S0022227520342401

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