GnT1IP-L specifically inhibits MGAT1 in the Golgi via its luminal domain

GnT1IP-L specifically inhibits MGAT1 in the Golgi via its luminal domain

Mouse GnT1IP-L, and membrane-bound GnT1IP-S (MGAT4D) expressed in cultured cells inhibit MGAT1, the N-acetylglucosaminyltransferase that initiates the synthesis of hybrid and complex N-glycans. However, it is not known where in the secretory pathway GnT1IP-L inhibits MGAT1, nor whether GnT1IP-L inhi...

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Bibliographic Details
Main Authors: Hung-Hsiang Huang, Antti Hassinen, Subha Sundaram, Andrej-Nikolai Spiess, Sakari Kellokumpu, Pamela Stanley
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-09-01
Series:eLife
Subjects:
GnT1IP-L
MGAT1 inhibitor
complex N-glycans
Golgi interaction
spermatogenesis
Online Access:https://elifesciences.org/articles/08916

Internet

https://elifesciences.org/articles/08916

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