Modelling Proteasome and Proteasome Regulator Activities

Proteasomes are key proteases involved in a variety of processes ranging from the clearance of damaged proteins to the presentation of antigens to CD8+ T-lymphocytes. Which cleavage sites are used within the target proteins and how fast these proteins are degraded have a profound impact on immune sy...

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Bibliographic Details
Main Authors: Juliane Liepe, Herman-Georg Holzhütter, Peter M. Kloetzel, Michael P. H. Stumpf, Michele Mishto
Format: Article
Language:English
Published: MDPI AG 2014-06-01
Series:Biomolecules
Subjects:
11S
19S
Online Access:http://www.mdpi.com/2218-273X/4/2/585