Chronic otitis media is initiated by a bulla cavitation defect in the FBXO11 mouse model

Auditory bulla cavitation defects are a cause of otitis media, but the normal cellular pattern of bulla mesenchyme regression and its failure are not well understood. In mice, neural-crest-derived mesenchyme occupies the bulla from embryonic day 17.5 (E17.5) to postnatal day 11 (P11) and then regres...

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Bibliographic Details
Main Authors: Jorge del-Pozo, Neil MacIntyre, Ali Azar, James Glover, Elspeth Milne, Michael Cheeseman
Format: Article
Language:English
Published: The Company of Biologists 2019-03-01
Series:Disease Models & Mechanisms
Subjects:
Online Access:http://dmm.biologists.org/content/12/3/dmm038315