Improved Human Erythropoiesis and Platelet Formation in Humanized NSGW41 Mice

Improved Human Erythropoiesis and Platelet Formation in Humanized NSGW41 Mice

Human erythro-megakaryopoiesis does not occur in humanized mouse models, preventing the in vivo analysis of human hematopoietic stem cell (HSC) differentiation into these lineages in a surrogate host. Here we show that stably engrafted KIT-deficient NOD/SCID Il2rg−/− KitW41/W41 (NSGW41) mice support...

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Bibliographic Details
Main Authors: Susann Rahmig, Romy Kronstein-Wiedemann, Juliane Fohgrub, Nicole Kronstein, Aleksandra Nevmerzhitskaya, Martin Bornhäuser, Max Gassmann, Alexander Platz, Rainer Ordemann, Torsten Tonn, Claudia Waskow
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671116301722

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http://www.sciencedirect.com/science/article/pii/S2213671116301722

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