The Genotype of the Donor for the (GT)n Polymorphism in the Promoter/Enhancer of FOXP3 Is Associated with the Development of Severe Acute GVHD but Does Not Affect the GVL Effect after Myeloablative HLA-Identical Allogeneic Stem Cell Transplantation.

The Genotype of the Donor for the (GT)n Polymorphism in the Promoter/Enhancer of FOXP3 Is Associated with the Development of Severe Acute GVHD but Does Not Affect the GVL Effect after Myeloablative HLA-Identical Allogeneic Stem Cell Transplantation.

The FOXP3 gene encodes for a protein (Foxp3) involved in the development and functional activity of regulatory T cells (CD4+/CD25+/Foxp3+), which exert regulatory and suppressive roles over the immune system. After allogeneic stem cell transplantation, regulatory T cells are known to mitigate graft...

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Main Authors: Víctor Noriega, Carolina Martínez-Laperche, Elena Buces, Marjorie Pion, Noemí Sánchez-Hernández, Beatriz Martín-Antonio, Vicent Guillem, Anna Bosch-Vizcaya, Leyre Bento, Milagros González-Rivera, Pascual Balsalobre, Mi Kwon, David Serrano, Jorge Gayoso, Rafael de la Cámara, Salut Brunet, Rafael Rojas-Contreras, José B Nieto, Carmen Martínez, Marcos Gónzalez, Ildefonso Espigado, Juan C Vallejo, Antonia Sampol, Antonio Jiménez-Velasco, Alvaro Urbano-Ispizua, Carlos Solano, David Gallardo, José L Díez-Martín, Ismael Buño, Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH)
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4608671?pdf=render

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http://europepmc.org/articles/PMC4608671?pdf=render

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