Nebulized Colistin in Ventilator-Associated Pneumonia and Tracheobronchitis: Historical Background, Pharmacokinetics and Perspectives

Nebulized Colistin in Ventilator-Associated Pneumonia and Tracheobronchitis: Historical Background, Pharmacokinetics and Perspectives

Clinical evidence suggests that nebulized colistimethate sodium (CMS) has benefits for treating lower respiratory tract infections caused by multidrug-resistant Gram-negative bacteria (GNB). Colistin is positively charged, while CMS is negatively charged, and both have a high molecular mass and are...

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Bibliographic Details
Main Authors: Yinggang Zhu, Antoine Monsel, Jason A. Roberts, Konstantinos Pontikis, Olivier Mimoz, Jordi Rello, Jieming Qu, Jean-Jacques Rouby, on behalf of the European Investigator Network for Nebulized Antibiotics in Ventilator-Associated Pneumonia (ENAVAP)
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Microorganisms
Subjects:
nebulized polymyxin
nebulized colistimethate sodium
colistin
multidrug resistant gram-negative bacteria
ventilator-associated pneumonia
ventilator-associated tracheobronchitis
Online Access:https://www.mdpi.com/2076-2607/9/6/1154

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https://www.mdpi.com/2076-2607/9/6/1154

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