Nebulized Colistin in Ventilator-Associated Pneumonia and Tracheobronchitis: Historical Background, Pharmacokinetics and Perspectives
Clinical evidence suggests that nebulized colistimethate sodium (CMS) has benefits for treating lower respiratory tract infections caused by multidrug-resistant Gram-negative bacteria (GNB). Colistin is positively charged, while CMS is negatively charged, and both have a high molecular mass and are...
Main Authors: | Yinggang Zhu, Antoine Monsel, Jason A. Roberts, Konstantinos Pontikis, Olivier Mimoz, Jordi Rello, Jieming Qu, Jean-Jacques Rouby, on behalf of the European Investigator Network for Nebulized Antibiotics in Ventilator-Associated Pneumonia (ENAVAP) |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-05-01
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Series: | Microorganisms |
Subjects: | |
Online Access: | https://www.mdpi.com/2076-2607/9/6/1154 |
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