Atovaquone Suppresses Triple-Negative Breast Tumor Growth by Reducing Immune-Suppressive Cells

Atovaquone Suppresses Triple-Negative Breast Tumor Growth by Reducing Immune-Suppressive Cells

A major contributing factor in triple-negative breast cancer progression is its ability to evade immune surveillance. One mechanism for this immunosuppression is through ribosomal protein S19 (RPS19), which facilitates myeloid-derived suppressor cells (MDSCs) recruitment in tumors, which generate cy...

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Bibliographic Details
Main Authors: Nehal Gupta, Shreyas Gaikwad, Itishree Kaushik, Stephen E. Wright, Maciej M. Markiewski, Sanjay K. Srivastava
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
myeloid-derived tumor-suppressor cells
atovaquone
repurposing
triple-negative breast cancer
regulatory T cells
cytokines
Online Access:https://www.mdpi.com/1422-0067/22/10/5150

Internet

https://www.mdpi.com/1422-0067/22/10/5150

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