Phosphorylation of ribosomal protein S6 kinase 1 at Thr421/Ser424 and dephosphorylation at Thr389 regulates SP600125-induced polyploidization of megakaryocytic cell lines.

Phosphorylation of ribosomal protein S6 kinase 1 at Thr421/Ser424 and dephosphorylation at Thr389 regulates SP600125-induced polyploidization of megakaryocytic cell lines.

Megakaryocytes (MKs) are one of the few cell types that become polyploid; however, the mechanisms by which these cells are designated to become polyploid are not fully understood. In this investigation, we successfully established two relatively synchronous polyploid cell models by inducing Dami and...

Full description

Bibliographic Details
Main Authors: Chang-Ling Li, Jin-Gang Yang, Di Lin, Yong-Shan Zhao, Shuo Liu, Si-Ning Xing, Song Zhao, Cong-Qin Chen, Zhi-Ming Jiang, Fei-Fei Pu, Jian-Ping Cao, Dong-Chu Ma
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4259319?pdf=render

Internet

http://europepmc.org/articles/PMC4259319?pdf=render

Similar Items