Development to term of cloned cattle derived from donor cells treated with valproic acid.

Development to term of cloned cattle derived from donor cells treated with valproic acid.

Cloning of mammals by somatic cell nuclear transfer (SCNT) is still plagued by low efficiency. The epigenetic modifications established during cellular differentiation are a major factor determining this low efficiency as they act as epigenetic barriers restricting reprogramming of somatic nuclei. I...

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Bibliographic Details
Main Authors: Juliano Rodrigues Sangalli, Marcos Roberto Chiaratti, Tiago Henrique Camara De Bem, Reno Roldi de Araújo, Fabiana Fernandes Bressan, Rafael Vilar Sampaio, Felipe Perecin, Lawrence Charles Smith, Willian Allan King, Flávio Vieira Meirelles
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24959750/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24959750/?tool=EBI

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