Diabetes promotes invasive pancreatic cancer by increasing systemic and tumour carbonyl stress in Kras G12D/+ mice

Diabetes promotes invasive pancreatic cancer by increasing systemic and tumour carbonyl stress in Kras G12D/+ mice

Abstract Background Type 1 and 2 diabetes confer an increased risk of pancreatic cancer (PaC) of similar magnitude, suggesting a common mechanism. The recent finding that PaC incidence increases linearly with increasing fasting glucose levels supports a central role for hyperglycaemia, which is know...

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Bibliographic Details
Main Authors: Stefano Menini, Carla Iacobini, Luisa de Latouliere, Isabella Manni, Martina Vitale, Emanuela Pilozzi, Carlo Pesce, Paola Cappello, Francesco Novelli, Giulia Piaggio, Giuseppe Pugliese
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Pancreatic ductal adenocarcinoma
Hyperglycaemia
Reactive carbonyl species
Methylglyoxal
Advanced glycation end-products
Carnosine derivatives
Online Access:http://link.springer.com/article/10.1186/s13046-020-01665-0

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http://link.springer.com/article/10.1186/s13046-020-01665-0

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