Acidosis Decreases c-Myc Oncogene Expression in Human Lymphoma Cells: A Role for the Proton-Sensing G Protein-Coupled Receptor TDAG8

Acidosis Decreases c-Myc Oncogene Expression in Human Lymphoma Cells: A Role for the Proton-Sensing G Protein-Coupled Receptor TDAG8

Acidosis is a biochemical hallmark of the tumor microenvironment. Here, we report that acute acidosis decreases c-Myc oncogene expression in U937 human lymphoma cells. The level of c-Myc transcripts, but not mRNA or protein stability, contributes to c-Myc protein reduction under acidosis. The pH-sen...

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Bibliographic Details
Main Authors: Zhigang Li, Lixue Dong, Eric Dean, Li V. Yang
Format: Article
Language:English
Published: MDPI AG 2013-10-01
Series:International Journal of Molecular Sciences
Subjects:
acidosis
tumor microenvironment
TDAG8
GPR65
c-Myc
Online Access:http://www.mdpi.com/1422-0067/14/10/20236

Internet

http://www.mdpi.com/1422-0067/14/10/20236

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