Alzheimer’s Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia

Alzheimer’s Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia

Microglia are key in the homeostatic well-being of the brain and microglial dysfunction has been implicated in neurodegenerative disorders such as Alzheimer’s disease (AD). Due to the many limitations to study microglia in situ or isolated for large scale drug discovery applications, there is a high...

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Bibliographic Details
Main Authors: Marvin Reich, Iñaki Paris, Martin Ebeling, Nadine Dahm, Christophe Schweitzer, Dieter Reinhardt, Roland Schmucki, Megana Prasad, Fabian Köchl, Marcel Leist, Sally A. Cowley, Jitao David Zhang, Christoph Patsch, Simon Gutbier, Markus Britschgi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
iPSC (induced pluripotent stem cell)
microglia
cell culture protocols
drug development
TREM2 (triggering receptor expressed on myeloid cells)
Alzheimer’s disease (AD)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.617860/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2020.617860/full

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