Targeting Hippo coactivator YAP1 through BET bromodomain inhibition in esophageal adenocarcinoma

Targeting Hippo coactivator YAP1 through BET bromodomain inhibition in esophageal adenocarcinoma

Hippo/YAP1 signaling is a major regulator of organ size, cancer stemness, and aggressive phenotype. Thus, targeting YAP1 may provide a novel therapeutic strategy for tumors with high YAP1 expression in esophageal cancer (EC). Chromatin immunoprecipitation (ChiP) and quantitative ChiP‐PCR were used t...

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Bibliographic Details
Main Authors: Shumei Song, Yuan Li, Yan Xu, Lang Ma, Melissa Pool Pizzi, Jiankang Jin, Ailing W Scott, Longfei Huo, Ying Wang, Jeffrey H. Lee, Manoop S. Bhutani, Brian Weston, Namita D Shanbhag, Randy L. Johnson, Jaffer A. Ajani
Format: Article
Language:English
Published: Wiley 2020-06-01
Series:Molecular Oncology
Subjects:
BRD4
CSCs
esophageal cancer
Hippo/YAP1
JQ1
therapy resistance
Online Access:https://doi.org/10.1002/1878-0261.12667

Internet

https://doi.org/10.1002/1878-0261.12667

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