Antioxidant Nanoparticles for Concerted Inhibition of α-Synuclein Fibrillization, and Attenuation of Microglial Intracellular Aggregation and Activation

Antioxidant Nanoparticles for Concerted Inhibition of α-Synuclein Fibrillization, and Attenuation of Microglial Intracellular Aggregation and Activation

Parkinson’s Disease is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta, the extracellular accumulation of toxic α-synuclein (αSYN) aggregates, and neuroinflammation. Microglia, resident macrophages of the brain, are one of the critical cell types involved in n...

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Bibliographic Details
Main Authors: Nanxia Zhao, Xue Yang, Hannah R. Calvelli, Yue Cao, Nicola L. Francis, Rebecca A. Chmielowski, Laurie B. Joseph, Zhiping P. Pang, Kathryn E. Uhrich, Jean Baum, Prabhas V. Moghe
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
Parkinson’s disease
microglia
alpha synuclein
ferulic acid
tannic acid
nanomedicine
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00112/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2020.00112/full

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