Aberrant Chloride Intracellular Channel 4 Expression Is Associated With Adverse Outcome in Cytogenetically Normal Acute Myeloid Leukemia

Aberrant Chloride Intracellular Channel 4 Expression Is Associated With Adverse Outcome in Cytogenetically Normal Acute Myeloid Leukemia

Background and Methods: Acute myeloid leukemia (AML), which starts in the bone marrow, is a group of hematopoietic stem cell disorders. Chloride intracellular channel 4 (CLIC4) is regulated by p53, c-Myc, and TGF-β. It induces the NF-κB-dependent activation of HIF (hypoxia-inducible factor) and part...

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Bibliographic Details
Main Authors: Sai Huang, Zhi Huang, Ping Chen, Cong Feng
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Oncology
Subjects:
CLIC4
expression
prognostic biomarker
CN-AML
adverse outcome
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01648/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.01648/full

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