Inhibition of Acute Graft-versus-Host Disease with Retention of Graft-versus-Tumor Effects by Dimethyl Fumarate

Inhibition of Acute Graft-versus-Host Disease with Retention of Graft-versus-Tumor Effects by Dimethyl Fumarate

Acute graft-versus-host disease (aGVHD) remains a clinical challenge and a major source of morbidity and mortality following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Dimethyl fumarate (DMF), an activator of Nrf2, has been shown to have anti-inflammatory and immunomodulatory pr...

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Bibliographic Details
Main Authors: Jingjing Han, Shoubao Ma, Huanle Gong, Shuangzhu Liu, Lei Lei, Bo Hu, Yang Xu, Haiyan Liu, Depei Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
acute graft-versus-host disease
graft-versus-leukemia
Nrf2
dimethyl fumarate
Treg cells
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01605/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01605/full

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