Optimization of an in vitro bilayer model for studying the functional interplay between human primary retinal pigment epithelial and choroidal endothelial cells isolated from donor eyes

Optimization of an in vitro bilayer model for studying the functional interplay between human primary retinal pigment epithelial and choroidal endothelial cells isolated from donor eyes

Abstract Objective The microenvironment of outer retina is largely regulated by retinal pigment epithelium (RPE) and choroid. Damage to either of these layers lead to the development of age related macular degeneration (AMD). A simplified cell culture model that mimics the RPE/Bruch’s membrane (BM)...

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Bibliographic Details
Main Authors: Karthikka Palanisamy, Coral Karunakaran, Rajiv Raman, Subbulakshmi Chidambaram
Format: Article
Language:English
Published: BMC 2019-05-01
Series:BMC Research Notes
Subjects:
Bilayer model
FITC dextran permeability
hRPE
hCEC
VEGF
Online Access:http://link.springer.com/article/10.1186/s13104-019-4333-x

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http://link.springer.com/article/10.1186/s13104-019-4333-x

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