Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health

Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health

Abstract Background Tobacco smoking is a risk factor for multiple diseases, including cardiovascular disease and diabetes. Many smoking-associated signals have been detected in the blood methylome, but the extent to which these changes are widespread to metabolically relevant tissues, and impact gen...

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Bibliographic Details
Main Authors: Pei-Chien Tsai, Craig A. Glastonbury, Melissa N. Eliot, Sailalitha Bollepalli, Idil Yet, Juan E. Castillo-Fernandez, Elena Carnero-Montoro, Thomas Hardiman, Tiphaine C. Martin, Alice Vickers, Massimo Mangino, Kirsten Ward, Kirsi H. Pietiläinen, Panos Deloukas, Tim D. Spector, Ana Viñuela, Eric B. Loucks, Miina Ollikainen, Karl T. Kelsey, Kerrin S. Small, Jordana T. Bell
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Clinical Epigenetics
Subjects:
Smoking
DNA methylation
Gene expression
RNA-sequencing
Adipose tissue
Online Access:http://link.springer.com/article/10.1186/s13148-018-0558-0

Internet

http://link.springer.com/article/10.1186/s13148-018-0558-0

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