Relevance of QuantiFERON-TB Gold Plus and Heparin-Binding Hemagglutinin Interferon-γ Release Assays for Monitoring of Pulmonary Tuberculosis Clearance: A Multicentered Study

Relevance of QuantiFERON-TB Gold Plus and Heparin-Binding Hemagglutinin Interferon-γ Release Assays for Monitoring of Pulmonary Tuberculosis Clearance: A Multicentered Study

BackgroundTuberculosis (TB) is a leading infectious cause of death. To improve treatment efficacy, quicker monitoring methods are needed. The objective of this study was to monitor the response to a heparin-binding hemagglutinin (HBHA) interferon-γ (IFN-γ) release assay (IGRA) and QuantiFERON-TB Gol...

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Main Authors: Carole Chedid, Eka Kokhreidze, Nestani Tukvadze, Sayera Banu, Mohammad Khaja Mafij Uddin, Samanta Biswas, Graciela Russomando, Chyntia Carolina Díaz Acosta, Rossana Arenas, Paulo PR. Ranaivomanana, Crisca Razafimahatratra, Perlinot Herindrainy, Julio Rakotonirina, Antso Hasina Raherinandrasana, Niaina Rakotosamimanana, Monzer Hamze, Mohamad Bachar Ismail, Rim Bayaa, Jean-Luc Berland, Flavio De Maio, Giovanni Delogu, Hubert Endtz, Florence Ader, Delia Goletti, Jonathan Hoffmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
tuberculosis
immunomonitoring
interferon-gamma release assays
heparin-binding haemagglutinin adhesin
QuantiFERON
treatment monitoring
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.616450/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2020.616450/full

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