Rescue of cognitive deficits in APP/PS1 mice by accelerating the aggregation of β-amyloid peptide

Rescue of cognitive deficits in APP/PS1 mice by accelerating the aggregation of β-amyloid peptide

Abstract Background Brain amyloid deposition is one of the main pathological characteristics of Alzheimer’s disease (AD). Soluble oligomers formed during the process that causes β-amyloid (Aβ) to aggregate into plaques are considered to have major neurotoxicity. Currently, drug development for the t...

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Bibliographic Details
Main Authors: Jian-Xiang Zhang, Yi-Hui Lai, Pan-Ying Mi, Xue-Ling Dai, Ran Zhang, Zhan-Jun Zhang, Shu-Juan Zhang, Xi-Wen Zhang, Xi-Yan Zhang, Bing-Yu Yang, Dong-Mei Cui, Chen Zhang, Chang-Qi Zhao, Fei Dou
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
β-Amyloid
Oligomers
Globulomers
Flavonoid
Online Access:https://doi.org/10.1186/s13195-019-0560-6

Internet

https://doi.org/10.1186/s13195-019-0560-6

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