APOE-ε4 risk variant for Alzheimer's disease modifies the association between cognitive performance and cerebral morphology in healthy middle-aged individuals

APOE-ε4 risk variant for Alzheimer's disease modifies the association between cognitive performance and cerebral morphology in healthy middle-aged individuals

The APOE-ε4 genotype is the highest genetic risk factor for Alzheimer's disease (AD). In cognitively unimpaired individuals, it has been related to altered brain morphology, function and earlier amyloid beta accumulation. However, its impact on cognitive performance is less evident. Here, we ex...

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Bibliographic Details
Main Authors: Raffaele Cacciaglia, José Luis Molinuevo, Carles Falcón, Gonzalo Sánchez-Benavides, Nina Gramunt, Anna Brugulat-Serrat, Manel Esteller, Sebastián Morán, Karine Fauria, Juan Domingo Gispert
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:NeuroImage: Clinical
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158219301688

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http://www.sciencedirect.com/science/article/pii/S2213158219301688

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