Estrogen-Related Receptor γ Induces Angiogenesis and Extracellular Matrix Degradation of Temporomandibular Joint Osteoarthritis in Rats

Estrogen-Related Receptor γ Induces Angiogenesis and Extracellular Matrix Degradation of Temporomandibular Joint Osteoarthritis in Rats

The main causes of cartilage destruction during temporomandibular joint osteoarthritis (TMJOA) are extracellular matrix degradation and angiogenesis, accompanied by an increased level of matrix-degrading enzymes and proangiogenic factors. Interleukin 6 and extracellular signal–regulated kinase (ERK)...

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Bibliographic Details
Main Authors: Haoming Zhao, Shaopeng Liu, Chuan Ma, Shixing Ma, Guokun Chen, Lingyu Yuan, Lei Chen, Huaqiang Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Pharmacology
Subjects:
osteoarthritis (OA)
temporomandibular joint (TMJ)
estrogen-related receptor γ (ERRγ)
extracellular matrix degradation
angiogenesis
interleukin 6
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01290/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01290/full

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