Malate and Aspartate Increase L-Arginine and Nitric Oxide and Attenuate Hypertension

Malate and Aspartate Increase L-Arginine and Nitric Oxide and Attenuate Hypertension

Fumarase catalyzes the interconversion of fumarate and L-malate in the tricarboxylic acid cycle. The Dahl salt-sensitive (SS) rat, a model of salt-sensitive hypertension, exhibits fumarase insufficiencies. To investigate the mechanism mediating the effect of fumarase-related metabolites on hypertens...

Full description

Bibliographic Details
Main Authors: Entai Hou, Na Sun, Fuchang Zhang, Chenyang Zhao, Kristie Usa, Mingyu Liang, Zhongmin Tian
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Cell Reports
Subjects:
salt
hypertension
kidney
metabolism
nitric oxide
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717306009

Internet

http://www.sciencedirect.com/science/article/pii/S2211124717306009

Similar Items