A Novel Drug-Mouse Phenotypic Similarity Method Detects Molecular Determinants of Drug Effects.

The molecular mechanisms that translate drug treatment into beneficial and unwanted effects are largely unknown. We present here a novel approach to detect gene-drug and gene-side effect associations based on the phenotypic similarity of drugs and single gene perturbations in mice that account for t...

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Bibliographic Details
Main Authors: Jeanette Prinz, Ingo Vogt, Gianluca Adornetto, Mónica Campillos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-09-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC5038975?pdf=render