Histidine-Triad Hydrolases Provide Resistance to Peptide-Nucleotide Antibiotics

Histidine-Triad Hydrolases Provide Resistance to Peptide-Nucleotide Antibiotics

Uncovering the mechanisms of resistance is a required step for countering the looming antibiotic resistance crisis. In this communication, we show how universally conserved histidine-triad hydrolases provide resistance to microcin C, a potent inhibitor of bacterial protein synthesis.The Escherichia...

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Bibliographic Details
Main Authors: Eldar Yagmurov, Darya Tsibulskaya, Alexey Livenskyi, Marina Serebryakova, Yury I. Wolf, Sergei Borukhov, Konstantin Severinov, Svetlana Dubiley
Format: Article
Language:English
Published: American Society for Microbiology 2020-04-01
Series:mBio
Subjects:
hint
ripps
antibiotics
histidine-triad proteins
microcin c
peptide-nucleotides
Online Access:https://doi.org/10.1128/mBio.00497-20

Internet

https://doi.org/10.1128/mBio.00497-20

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