Anti-EMT properties of CoQ0 attributed to PI3K/AKT/NFKB/MMP-9 signaling pathway through ROS-mediated apoptosis

Anti-EMT properties of CoQ0 attributed to PI3K/AKT/NFKB/MMP-9 signaling pathway through ROS-mediated apoptosis

Abstract Background Breast cancer is the most prevalent cancer among women. In triple-negative breast cancer (TNBC) cells, a novel quinone derivative, coenzyme Q0 (CoQ0), promotes apoptosis and cell-cycle arrest. This study explored the anti-epithelial–mesenchymal transition (EMT) and antimetastatic...

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Bibliographic Details
Main Authors: Hsin-Ling Yang, Varadharajan Thiyagarajan, Pei-Chun Shen, Dony Chacko Mathew, Kai-Yuan Lin, Jiunn-Wang Liao, You-Cheng Hseu
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
CoQ0
TNBC
EMT
Metastasis
Human epidermal growth factor receptor 2
TGF-β1
Online Access:http://link.springer.com/article/10.1186/s13046-019-1196-x

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http://link.springer.com/article/10.1186/s13046-019-1196-x

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