Amyloid precursor protein elevates fusion of promyelocytic leukemia nuclear bodies in human hippocampal areas with high plaque load

Amyloid precursor protein elevates fusion of promyelocytic leukemia nuclear bodies in human hippocampal areas with high plaque load

Abstract The amyloid precursor protein (APP) is a type I transmembrane protein with unknown physiological function but potential impact in neurodegeneration. The current study demonstrates that APP signals to the nucleus causing the generation of aggregates consisting of its adapter protein FE65, th...

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Bibliographic Details
Main Authors: David Marks, Natalie Heinen, Lisa Bachmann, Sophia Meermeyer, Michelle Werner, Lucia Gallego, Peter Hemmerich, Verian Bader, Konstanze F. Winklhofer, Elisabeth Schröder, Shirley K. Knauer, Thorsten Müller
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease
APP-CT50
PML
IPSC-derived cerebral organoids
3D culture
Nuclear complexes
Online Access:https://doi.org/10.1186/s40478-021-01174-x

Internet

https://doi.org/10.1186/s40478-021-01174-x

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