Phosphatase PPM1A negatively regulates P-TEFb function in resting CD4T<sup>+</sup> T cells and inhibits HIV-1 gene expression

Phosphatase PPM1A negatively regulates P-TEFb function in resting CD4T<sup>+</sup> T cells and inhibits HIV-1 gene expression

<p>Abstract</p> <p>Background</p> <p>Processive elongation of the integrated HIV-1 provirus is dependent on recruitment of P-TEFb by the viral Tat protein to the viral TAR RNA element. P-TEFb kinase activity requires phosphorylation of Thr186 in the T-loop of the CDK9 s...

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Bibliographic Details
Main Authors: Budhiraja Sona, Ramakrishnan Rajesh, Rice Andrew P
Format: Article
Language:English
Published: BMC 2012-06-01
Series:Retrovirology
Subjects:
P-TEFb
HIV-1
CDK9
PPM1A
Online Access:http://www.retrovirology.com/content/9/1/52

Internet

http://www.retrovirology.com/content/9/1/52

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