Huntington's disease leads to decrease of GABA-A tonic subunits in the D2 neostriatal pathway and their relocalization into the synaptic cleft

Huntington's disease leads to decrease of GABA-A tonic subunits in the D2 neostriatal pathway and their relocalization into the synaptic cleft

GABA is a widely distributed inhibitory neurotransmitter. GABA-A receptors are hetero-pentameric channels assembled in multiple combinations from 19 available subunits; this diversity mediates phasic and tonic inhibitory synaptic potentials. Whereas GABA-A phasic receptors are located within the syn...

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Bibliographic Details
Main Authors: Abraham Rosas-Arellano, Carlos Tejeda-Guzmán, Enrique Lorca-Ponce, Lourdes Palma-Tirado, Carola A. Mantellero, Patricio Rojas, Fanis Missirlis, Maite A. Castro
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Neurobiology of Disease
Subjects:
Tonic inhibition
Extrasynaptic and perisynaptic GABA-A receptors
Chorea
D2 medium-size spiny neurons
YAC128 mouse model
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117302681

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http://www.sciencedirect.com/science/article/pii/S0969996117302681

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