HPV16-E6 Oncoprotein Activates TGF-β and Wnt/β-Catenin Pathways in the Epithelium-Mesenchymal Transition of Cataracts in a Transgenic Mouse Model

HPV16-E6 Oncoprotein Activates TGF-β and Wnt/β-Catenin Pathways in the Epithelium-Mesenchymal Transition of Cataracts in a Transgenic Mouse Model

Objective. This work aimed to determine if cataractous changes associated with EMT occurring in the K14E6 mice lenses are associated with TGF-β and Wnt/β-catenin signaling activation. Materials and Methods. Cataracts of K14E6 mice were analysed histologically; and components of TGF-β and Wnt/β-caten...

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Main Authors: Genaro Rodríguez-Uribe, Nicolas Serafín-Higuera, Gabriela Damian-Morales, Enoc Mariano Cortés-Malagón, Vicky García-Hernández, Odette Verdejo-Torres, Jessica Paulina Campos-Blázquez, Cynthia R. Trejo-Muñoz, Rubén Gerardo Contreras, Rodolfo Ocadiz-Delgado, Carmen Palacios-Reyes, Paul F. Lambert, Anne E. Griep, Teresa Mancilla-Percino, Jaime Escobar-Herrera, Elizabeth Álvarez-Ríos, Carlos Ugarte-Briones, José Moreno, Patricio Gariglio, José Bonilla-Delgado
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2018/2847873

Internet

http://dx.doi.org/10.1155/2018/2847873

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