Protection of Mice from Acute Graft-versus-Host Disease Requires CD28 Co-stimulation on Donor CD4+ Foxp3+ Regulatory T Cells

Protection of Mice from Acute Graft-versus-Host Disease Requires CD28 Co-stimulation on Donor CD4+ Foxp3+ Regulatory T Cells

Acute graft-versus-host disease (aGvHD) is a major cause of morbidity and mortality after allogeneic hematopoietic stem cell plus T cell transplantation (allo-HSCT). In this study, we investigated the requirement for CD28 co-stimulation of donor CD4+ conventional (CD4+CD25−Foxp3−, Tconv) and regulat...

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Bibliographic Details
Main Authors: Anna Uri, Sandra Werner, Fred Lühder, Thomas Hünig, Thomas Kerkau, Niklas Beyersdorf
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Immunology
Subjects:
acute graft-versus-host disease
CD28
co-stimulation
regulatory T cells
inducible deletion
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00721/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00721/full

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