Epigenetic Determinants of CYP1A1 Induction by the Aryl Hydrocarbon Receptor Agonist 3,3',4,4',5-Pentachlorobiphenyl (PCB 126)

Epigenetic Determinants of CYP1A1 Induction by the Aryl Hydrocarbon Receptor Agonist 3,3',4,4',5-Pentachlorobiphenyl (PCB 126)

Many enzymes involved in xenobiotic metabolism, including cytochrome P450 (CYP) 1A1, are regulated by the aryl hydrocarbon receptor (AhR). 3,3',4,4',5-Penta chlorobiphenyl (PCB 126) is a potent ligand for AhR and can thus induce the expression of CYP1A1. Interestingly, we observed that hu...

Full description

Bibliographic Details
Main Authors: Sabine U. Vorrink, Danielle R. Hudachek, Frederick E. Domann
Format: Article
Language:English
Published: MDPI AG 2014-08-01
Series:International Journal of Molecular Sciences
Subjects:
aryl hydrocarbon receptor
chromatin accessibility
DNA methylation
epigenetic regulation
polychlorinated biphenyls
Online Access:http://www.mdpi.com/1422-0067/15/8/13916

Internet

http://www.mdpi.com/1422-0067/15/8/13916

Similar Items