Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT₁A and 5-HT₇ Antagonists in Animal Models.

The aim of this study was to further characterize pharmacological properties of two phenylpiperazine derivatives: 1-{2-[2-(2,6-dimethlphenoxy)ethoxy]ethyl}-4-(2-methoxyphenyl)piperazynine hydrochloride (HBK-14) and 2-[2-(2-chloro-6-methylphenoxy)ethoxy]ethyl-4-(2- methoxyphenyl)piperazynine dihydroc...

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Main Authors: Karolina Pytka, Anna Partyka, Magdalena Jastrzębska-Więsek, Agata Siwek, Monika Głuch-Lutwin, Barbara Mordyl, Grzegorz Kazek, Anna Rapacz, Adrian Olczyk, Adam Gałuszka, Marian Błachuta, Anna Waszkielewicz, Henryk Marona, Jacek Sapa, Barbara Filipek, Anna Wesołowska
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4640659?pdf=render