Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease
Abstract Background There is no consensus about which hippocampal subfields become atrophic earliest in the course of Alzheimer's disease (AD). Methods Thirty AD patients, 41 mild cognitive impairment (MCI) patients, and 38 healthy controls (HCs) underwent cerebral magnetic resonance imaging (w...
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doaj-3bf62f3f604d47a584c643ecec4ea6fa2020-11-25T03:43:18ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292015-03-0111243210.1016/j.dadm.2014.12.001Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's diseaseGiovanni A. Carlesimo0Fabrizio Piras1Maria Donata Orfei2Mariangela Iorio3Carlo Caltagirone4Gianfranco Spalletta5Department of NeuroscienceTor Vergata UniversityRomeItalyDepartment of Clinical and Behavioral NeurologySanta Lucia FoundationRomeItalyDepartment of Clinical and Behavioral NeurologySanta Lucia FoundationRomeItalyDepartment of Clinical and Behavioral NeurologySanta Lucia FoundationRomeItalyDepartment of NeuroscienceTor Vergata UniversityRomeItalyDepartment of Clinical and Behavioral NeurologySanta Lucia FoundationRomeItalyAbstract Background There is no consensus about which hippocampal subfields become atrophic earliest in the course of Alzheimer's disease (AD). Methods Thirty AD patients, 41 mild cognitive impairment (MCI) patients, and 38 healthy controls (HCs) underwent cerebral magnetic resonance imaging (with an automated segmentation protocol for the volumetric analysis of hippocampal subfields) and a test of immediate and delayed recall of a 15‐word list. Results The volumes of the presubiculum and subiculum presented the most remarkable reduction in the patient's groups. In the MCI group, only the volumes of presubiculum and subiculum predicted performance on the memory tests. In AD patients, the volumes of all hippocampal subfields (with the notable exception of the CA1) predicted memory scores. Conclusions Our data point to a prevalent atrophy of the presubicular‐subicular complex from the early phases of AD. This finding is consistent with neuropathological observations in AD patients and probably reflects the severe degeneration of the perforant pathway while penetrating the hippocampus through the subicular field in its course from the entorhinal cortex to the dentate gyrus.https://doi.org/10.1016/j.dadm.2014.12.001Alzheimer's diseaseMild cognitive impairmentMemoryStructural MRIBrain atrophy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Giovanni A. Carlesimo Fabrizio Piras Maria Donata Orfei Mariangela Iorio Carlo Caltagirone Gianfranco Spalletta |
spellingShingle |
Giovanni A. Carlesimo Fabrizio Piras Maria Donata Orfei Mariangela Iorio Carlo Caltagirone Gianfranco Spalletta Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Alzheimer's disease Mild cognitive impairment Memory Structural MRI Brain atrophy |
author_facet |
Giovanni A. Carlesimo Fabrizio Piras Maria Donata Orfei Mariangela Iorio Carlo Caltagirone Gianfranco Spalletta |
author_sort |
Giovanni A. Carlesimo |
title |
Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease |
title_short |
Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease |
title_full |
Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease |
title_fullStr |
Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease |
title_full_unstemmed |
Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease |
title_sort |
atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of alzheimer's disease |
publisher |
Wiley |
series |
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
issn |
2352-8729 |
publishDate |
2015-03-01 |
description |
Abstract Background There is no consensus about which hippocampal subfields become atrophic earliest in the course of Alzheimer's disease (AD). Methods Thirty AD patients, 41 mild cognitive impairment (MCI) patients, and 38 healthy controls (HCs) underwent cerebral magnetic resonance imaging (with an automated segmentation protocol for the volumetric analysis of hippocampal subfields) and a test of immediate and delayed recall of a 15‐word list. Results The volumes of the presubiculum and subiculum presented the most remarkable reduction in the patient's groups. In the MCI group, only the volumes of presubiculum and subiculum predicted performance on the memory tests. In AD patients, the volumes of all hippocampal subfields (with the notable exception of the CA1) predicted memory scores. Conclusions Our data point to a prevalent atrophy of the presubicular‐subicular complex from the early phases of AD. This finding is consistent with neuropathological observations in AD patients and probably reflects the severe degeneration of the perforant pathway while penetrating the hippocampus through the subicular field in its course from the entorhinal cortex to the dentate gyrus. |
topic |
Alzheimer's disease Mild cognitive impairment Memory Structural MRI Brain atrophy |
url |
https://doi.org/10.1016/j.dadm.2014.12.001 |
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