A Simple Derivation of the Distribution of Pairwise Local Protein Sequence Alignment Scores
Confidence in pairwise alignments of biological sequences, obtained by various methods such as Blast or Smith-Waterman, is critical for automatic analyses of genomic data. In the asymptotic limit of long sequences, the Karlin-Altschul model computes a P-value assuming that the number of high scoring...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2008-01-01
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| Series: | Evolutionary Bioinformatics |
| Online Access: | https://doi.org/10.1177/117693430800400001 |