Aripiprazole Selectively Reduces Motor Tics in a Young Animal Model for Tourette’s Syndrome and Comorbid Attention Deficit and Hyperactivity Disorder

Aripiprazole Selectively Reduces Motor Tics in a Young Animal Model for Tourette’s Syndrome and Comorbid Attention Deficit and Hyperactivity Disorder

Tourette’s syndrome (TS) is a neurodevelopmental disorder characterized primarily by motor and vocal tics. Comorbidities such as attention deficit and hyperactivity disorder (ADHD) are observed in over 50% of TS patients. We applied aripiprazole in a juvenile rat model that displays motor tics and h...

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Bibliographic Details
Main Authors: Francesca Rizzo, Ester Nespoli, Alireza Abaei, Izhar Bar-Gad, Dinesh K. Deelchand, Jörg Fegert, Volker Rasche, Bastian Hengerer, Tobias M. Boeckers
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Neurology
Subjects:
adolescence
spontaneously hypertensive rat
1H magnetic resonance spectroscopy
attention-deficit/hyperactivity disorder
Tourette’s syndrome
striatum
Online Access:http://journal.frontiersin.org/article/10.3389/fneur.2018.00059/full

Internet

http://journal.frontiersin.org/article/10.3389/fneur.2018.00059/full

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