Trichostatin A ameliorates Alzheimer’s disease-related pathology and cognitive deficits by increasing albumin expression and Aβ clearance in APP/PS1 mice

Trichostatin A ameliorates Alzheimer’s disease-related pathology and cognitive deficits by increasing albumin expression and Aβ clearance in APP/PS1 mice

Abstract Background Alzheimer’s disease (AD) is an intractable neurodegenerative disorder in the elderly population, currently lacking a cure. Trichostatin A (TSA), a histone deacetylase inhibitor, showed some neuroprotective roles, but its pathology-improvement effects in AD are still uncertain, an...

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Bibliographic Details
Main Authors: Qiang Su, Tian Li, Pei-Feng He, Xue-Chun Lu, Qi Yu, Qi-Chao Gao, Zhao-Jun Wang, Mei-Na Wu, Dan Yang, Jin-Shun Qi
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Alzheimer’s Research & Therapy
Subjects:
Trichostatin A
APP/PS1 mice
Amyloid β clearance
Learning and memory
Albumin
Microglia
Online Access:https://doi.org/10.1186/s13195-020-00746-8

Internet

https://doi.org/10.1186/s13195-020-00746-8

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