Cryptotanshinone activates AMPK-TSC2 axis leading to inhibition of mTORC1 signaling in cancer cells

Cryptotanshinone activates AMPK-TSC2 axis leading to inhibition of mTORC1 signaling in cancer cells

Abstract Background Cryptotanshinone (CPT), a fat-soluble phenanthraquinone from Salvia miltiorrhiza Bunge, has been demonstrated to inhibit phosphorylation of p70 S6 kinase 1 (S6K1) and eukaryotic initiation factor 4E binding protein 1 (4E-BP1), a couple of direct downstream effectors of the mammal...

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Bibliographic Details
Main Authors: Wenxing Chen, Yanhong Pan, Siliang Wang, Yuping Liu, Guangying Chen, Liang Zhou, Wenting Ni, Aiyun Wang, Yin Lu
Format: Article
Language:English
Published: BMC 2017-01-01
Series:BMC Cancer
Subjects:
Cryptotanshinone
AMPK
TSC2
mTORC1
Online Access:http://link.springer.com/article/10.1186/s12885-016-3038-y

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http://link.springer.com/article/10.1186/s12885-016-3038-y

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