Ghrelin and its analogues, BIM-28131 and BIM-28125, improve body weight and regulate the expression of MuRF-1 and MAFbx in a rat heart failure model.

Ghrelin and its analogues, BIM-28131 and BIM-28125, improve body weight and regulate the expression of MuRF-1 and MAFbx in a rat heart failure model.

Cardiac cachexia is a serious complication of chronic heart failure with a prevalence of 10-16% and poor prognosis. There are no current therapy options for cardiac cachexia. Ghrelin is the natural ligand for the GHS-1a-receptor and a potential target for conditions associated with cachexia. Ghrelin...

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Bibliographic Details
Main Authors: Sandra Palus, Robert Schur, Yoshihiro J Akashi, Barbara Bockmeyer, Rakesh Datta, Heather Halem, Jesse Dong, Michael D Culler, Volker Adams, Stefan D Anker, Jochen Springer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3216926?pdf=render

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http://europepmc.org/articles/PMC3216926?pdf=render

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