High-Throughput Sequencing to Investigate Associations Between HLA Genes and Metamizole-Induced Agranulocytosis

High-Throughput Sequencing to Investigate Associations Between HLA Genes and Metamizole-Induced Agranulocytosis

Background and Objective: Agranulocytosis is a rare and potentially life-threatening complication of metamizole (dipyrone) intake that is characterized by a loss of circulating neutrophil granulocytes. While the mechanism underlying this adverse drug reaction is not well understood, involvement of t...

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Bibliographic Details
Main Authors: Anca Liliana Cismaru, Livia Grimm, Deborah Rudin, Luisa Ibañez, Evangelia Liakoni, Nicolas Bonadies, Reinhold Kreutz, Pär Hallberg, Mia Wadelius, EuDAC Collaborators, Manuel Haschke, Carlo R. Largiadèr, Ursula Amstutz
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Genetics
Subjects:
drug-induced agranulocytosis
metamizole (dipyrone)
HLA
pharmacogenetics
high-throughput sequencing
next generation sequencing
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00951/full

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https://www.frontiersin.org/article/10.3389/fgene.2020.00951/full

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