Novel Semi-Replicative Retroviral Vector Mediated Double Suicide Gene Transfer Enhances Antitumor Effects in Patient-Derived Glioblastoma Models

Novel Semi-Replicative Retroviral Vector Mediated Double Suicide Gene Transfer Enhances Antitumor Effects in Patient-Derived Glioblastoma Models

As glioblastomas are mostly localized infiltrative lesions, gene therapy based on the retroviral replicating vector (RRV) system is considered an attractive strategy. Combinations of multiple suicide genes can circumvent the limitations associated with each gene, achieving direct and synergistic cyt...

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Bibliographic Details
Main Authors: Mijeong Lee, Yeon-Soo Kim, Kyoungmin Lee, Moonkyung Kang, Hyemi Shin, Jeong-Woo Oh, Harim Koo, Donggeon Kim, Yejin Kim, Doo-Sik Kong, Do-Hyun Nam, Hye Won Lee
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Cancers
Subjects:
glioblastoma
patient-derived glioblastoma stem-like cells
semi- and pseudotyped-retroviral replicating vector
dual suicide gene therapy
bystander effect
Online Access:https://www.mdpi.com/2072-6694/11/8/1090

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https://www.mdpi.com/2072-6694/11/8/1090

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