Mouse Models of Achromatopsia in Addressing Temporal “Point of No Return” in Gene-Therapy

Mouse Models of Achromatopsia in Addressing Temporal “Point of No Return” in Gene-Therapy

Achromatopsia is characterized by amblyopia, photophobia, nystagmus, and color blindness. Previous animal models of achromatopsia have shown promising results using gene augmentation to restore cone function. However, the optimal therapeutic window to elicit recovery remains unknown. Here, we attemp...

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Bibliographic Details
Main Authors: Nan-Kai Wang, Pei-Kang Liu, Yang Kong, Sarah R. Levi, Wan-Chun Huang, Chun-Wei Hsu, Hung-Hsi Wang, Nelson Chen, Yun-Ju Tseng, Peter M. J. Quinn, Ming-Hong Tai, Chyuan-Sheng Lin, Stephen H. Tsang
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
achromatopsia
CNGA3
CRISPR
Online Access:https://www.mdpi.com/1422-0067/22/15/8069

Internet

https://www.mdpi.com/1422-0067/22/15/8069

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