Progression of Pulmonary Emphysema and Continued Increase in Ectodomain Shedding of Cell Adhesion Molecule 1 After Cessation of Cigarette Smoke Exposure in Mice

Progression of Pulmonary Emphysema and Continued Increase in Ectodomain Shedding of Cell Adhesion Molecule 1 After Cessation of Cigarette Smoke Exposure in Mice

Pulmonary emphysema usually arises in cigarette smokers, and often progresses after smoking cessation and even in ex-smokers. Lung-epithelial cell adhesion molecule 1 (CADM1), an immunoglobulin superfamily member, is extracellularly shed to produce a proapoptotic C-terminal fragment (CTF) within the...

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Bibliographic Details
Main Authors: Aritoshi Ri, Man Hagiyama, Takao Inoue, Azusa Yoneshige, Ryuichiro Kimura, Yoshinori Murakami, Akihiko Ito
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
pulmonary emphysema
animal model
histopathology
cell adhesion molecule 1
ectodomain shedding
ex-smoker
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2018.00052/full

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https://www.frontiersin.org/article/10.3389/fcell.2018.00052/full

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