DNA origami scaffold for studying intrinsically disordered proteins of the nuclear pore complex

DNA origami scaffold for studying intrinsically disordered proteins of the nuclear pore complex

FG-Nups are disordered proteins in the nuclear pore complex (NPC) where they selectively control nuclear transport. Here authors build NPC-mimics based on DNA origami rings which attach a certain numbers of Nups to analyse those nanopores by cryoEM and conductance measurements.

Bibliographic Details
Main Authors: Philip Ketterer, Adithya N. Ananth, Diederik S. Laman Trip, Ankur Mishra, Eva Bertosin, Mahipal Ganji, Jaco van der Torre, Patrick Onck, Hendrik Dietz, Cees Dekker
Format: Article
Language:English
Published: Nature Publishing Group 2018-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03313-w

Internet

https://doi.org/10.1038/s41467-018-03313-w

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