Molecular modelling and de novo fragment-based design of potential inhibitors of beta-tubulin gene of Necator americanus from natural products

Molecular modelling and de novo fragment-based design of potential inhibitors of beta-tubulin gene of Necator americanus from natural products

The emergence of drug resistance against the known hookworm drugs namely albendazole and mebendazole and their reduced efficacies necessitate the need for new drugs. Chemically diverse natural products present plausible templates to augment hookworm drug discovery. The present work utilized pharmaco...

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Bibliographic Details
Main Authors: Odame Agyapong, Seth O. Asiedu, Samuel K. Kwofie, Whelton A. Miller, III, Christian S. Parry, Robert A. Sowah, Michael D. Wilson
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Informatics in Medicine Unlocked
Subjects:
Necator americanus
Anthelmintics
Natural products
Pharmacoinformatics
Molecular modelling
Drug discovery
Online Access:http://www.sciencedirect.com/science/article/pii/S2352914821002136

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http://www.sciencedirect.com/science/article/pii/S2352914821002136

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