On the perplexingly low rate of transport of IgG2 across the human placenta.

On the perplexingly low rate of transport of IgG2 across the human placenta.

The neonatal receptor, FcRn, mediates both serum half-life extension as well as active transport of maternal IgG to the fetus during pregnancy. Therefore, transport efficiency and half-life go hand-in-hand. However, while the half-life of the human IgG2 subclass is comparable to IgG1, the placental...

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Bibliographic Details
Main Authors: Helga K Einarsdottir, Nigel M Stapleton, Sicco Scherjon, Jan Terje Andersen, Theo Rispens, C Ellen van der Schoot, Gestur Vidarsson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4177109?pdf=render

Internet

http://europepmc.org/articles/PMC4177109?pdf=render

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