KAT-Independent Gene Regulation by Tip60 Promotes ESC Self-Renewal but Not Pluripotency

KAT-Independent Gene Regulation by Tip60 Promotes ESC Self-Renewal but Not Pluripotency

Although histone-modifying enzymes are generally assumed to function in a manner dependent on their enzymatic activities, this assumption remains untested for many factors. Here, we show that the Tip60 (Kat5) lysine acetyltransferase (KAT), which is essential for embryonic stem cell (ESC) self-renew...

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Bibliographic Details
Main Authors: Diwash Acharya, Sarah J. Hainer, Yeonsoo Yoon, Feng Wang, Ingolf Bach, Jaime A. Rivera-Pérez, Thomas G. Fazzio
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Cell Reports
Subjects:
chromatin
embryonic stem cells
Tip60
Kat5
Ep400
acetyltransferase
self-renewal
differentiation
development
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717304606

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http://www.sciencedirect.com/science/article/pii/S2211124717304606

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